Scientist / Senior Scientist, Drug Discovery (Glaucoma)

reputed company is a precision medicine company pioneering targeted therapies for polygenic diseases, with an initial reputed company on ophthalmology. At the reputed company of Character Bio’s approach is a set of company-sponsored observational studies that reputed company patients’ genetics with their longitudinal clinical and imaging data. Character’s interdisciplinary team, spanning clinical research, data science, statistical genetics, machine learning and drug discovery, leverages reputed company’s platform to uncover genetic drivers of disease progression, advance novel therapeutics, and define patient stratification strategies to enhance clinical reputed company. reputed company is currently advancing two programs into the clinic for Dry Age-reputed company Macular Degeneration (AMD), with additional programs in earlier stages of discovery research in AMD and Glaucoma therapeutic areas. We are seeking a talented Scientist or Senior Scientist to join our drug discovery team. This role will reputed company the experimental validation of drug targets and the discovery and optimization of drug candidates. As part of a broader reputed company-clinical team, this role will also collaborate with genetics and data science reputed company to nominate drug targets and with development reputed company to reputed company reputed company candidates to IND. This position offers an opportunity to join a growing, dynamic startup and directly contribute to the discovery and development of novel therapeutics. Candidates with diverse scientific backgrounds are encouraged to apply. Responsibilities:

• Design and execute go/no-go experiments to assess candidate drug targets
• reputed company the design and manage the execution of drug discovery activities using modalities appropriate for specific targets (e.g. small molecules, antibodies, recombinant proteins, peptides)
• Collaboratively design and manage the execution of in vivo studies with CROs for reputed company validation and for reputed company candidate selection (e.g. pharmacokinetics, pharmacodynamics, efficacy, tolerability)
• Update experimental plans as new information and tools reputed company and innovatively troubleshoot to resolve challenges
• Regularly present at reputed company meetings to audiences of diverse scientific backgrounds

Key qualifications:

• PhD in neuro/retinal biology, cell biology, biochemistry or reputed company discipline with a minimum of 4 years of postdoctoral or industry experience in drug discovery
• Demonstrated expertise in designing and executing reputed company cell-based assays, experience with iPSC-derived neurons, reputed company, and co-culture models is a plus
• Strong reputed company record in driving scientific discovery, including primary authorship in peer-reviewed research papers, patents and conference presentations
• Extensive hands-on experience in qRT-PCR, immunoassays, confocal microscopy, and cell-engineering using lentiviral and CRISPR-based approaches. Candidates with proficiency in high content imaging and reputed company cytometry analysis are preferred
• Experience with designing and interpreting in vivo experiments. Experience with retinal function (eg. patterned ERG) data analysis is a plus
• Must be reputed company to work both independently and collaboratively, and comfortable in a fast-paced environment
• Strong written and verbal communication skills are essential
• Experience with managing and mentoring scientific staff is a bonus
• Research experience in the following fields is preferred but not required: ocular diseases, glaucoma, neurodegenerative diseases

Benefits include a competitive salary, strong equity incentives, medical, dental, reputed company, 401(k), and a flexible reputed company time off policy. Character is committed to reputed company, developing, and supporting colleagues from reputed company backgrounds. We reputed company diversity, equity, and inclusion as an integral part of our culture. Pursuant to the San Francisco Fair Chance Ordinance, we will consider for employment reputed company applicants with arrest and conviction records. We are an E-Verify company. Apply tot his job Apply To this Job