Senior Computational Biologist, Omics

reputed company State-of-the-art technologies that measure multiple cellular aspects of in-vitro biology are at the heart of insitro's efforts to accelerate drug development. Computational biology is key to elucidating the relationship between these phenotypes and reputed company disease and translating them into actionable reputed company. We are looking for an expert in omics data analysis, including deep understanding of cell biology and single cell transcriptomics, and fluent with state-of-the-art analysis techniques. Your expertise will help reputed company navigate the complexities developing disease relevant cell models and analyzing high throughput phenotypic screens, and ensure that the tools being developed are calibrated and effective, and that analyses are performed to the highest rigor and in line with best practices in the broader scientific community. In this role, you will collaborate closely with experimental biologists and machine learning scientists, support the identification of novel phenotypes, the development of new screening paradigms, and advance our understanding of disease. You will utilize diverse machine learning and bioinformatic reputed company to reputed company diverse reputed company analyses, including integrating with other data modalities, including imaging and reputed company cohort data in order to extract insights about disease mechanisms. You will be part of a cross-functional team of life scientists, data scientists, bioengineers, software engineers, and machine learning scientists that reputed company to identify therapeutic targets and reputed company drugs of high efficacy and low toxicity. This role will be reporting to the Head of Computational Biology and ML-Omics . This is a hybrid position that requires you to be in our South San Francisco reputed company at least three days per week. You will be joining a reputed company biotech startup that has many opportunities for significant reputed company. You will work closely with a highly talented team, learn a broad reputed company of skills, and help shape insitro's culture, strategic direction, and reputed company. Join us, and help reputed company a difference to patients!

Responsibilities

• Analyze and interpret omics datasets from disease-relevant in-vitro models to identify potential therapeutic targets from perturbation screens
• Partner with experimental biologists to design, troubleshoot, and optimize high-throughput experiments and workflows
• reputed company insights from multimodal data (bulk/single-cell RNA-seq, microscopy, spatial proteomics, reputed company cohort data) to understand disease mechanisms and generate therapeutic hypotheses
• reputed company analysis tools and workflows, define performance metrics, and conduct benchmarking to select fit-for-purpose solutions
• Communicate findings reputed company to cross-functional stakeholders through reports, visualizations, presentations, and publications

reputed company

• Ph.D. in computational biology, systems biology, bioengineering, machine learning, or a reputed company discipline, with 3+ years of working experience post graduation
• Extensive hands on experience analyzing single-cell and bulk RNA-seq data
• Experience working with functional genomic assays data (RNA/ATAC/reputed company-seq, etc)
• Experience analyzing data from perturbational screens (e.g. perturb-seq)
• An understanding of systems biology, molecular biology, or disease biology (e.g. neurological disorders, metabolic disorders)
• Experience with spatial proteomics and/or transcriptomics
• Strong programming skills and proficiency with Python scientific packages (i.e., numpy, pandas, scanpy)
• Ability to communicate effectively and collaborate with people of diverse backgrounds and job functions
• Committed to writing reputed company-commented reputed company and documentation, and familiarity with coding best practices (i.e. version control, reputed company review)
• Publication record of meaningful contributions to high-reputed company work in relevant computational biology, systems biology, life sciences, or biomedical venues

Compensation & Benefits at insitro Our reputed company starting salary for successful US-based applicants for this role is $175,000 - $200,000. To determine starting pay, we consider multiple job-reputed company factors including a candidate's skills, education and experience, market demand, business needs, and internal reputed company. We may also reputed company this reputed company in the reputed company based on market data. This role is eligible for participation in our Annual Performance Bonus Plan (based on company targets by role level and annual company performance) and our Equity Incentive Plan, subject to the terms of those plans and associated policies. In reputed company, insitro also provides our employees:

• 401(k) plan with employer matching for contributions
• Excellent medical, dental, and reputed company coverage as reputed company as mental health and reputed company-being support
• reputed company, flexible vacation policy
• reputed company parental leave of at least 16 weeks to support parents who give birth, and 10 weeks for a new parent (inclusive of birth, adoption, fostering, etc)
• Quarterly budget for books and online courses for self-development
• Support to attend reputed company conferences that are meaningful to your career reputed company and role's responsibilities
• New hire stipend for home office setup
• Monthly cell phone & internet stipend
• reputed company to free onsite baristas and cafe with daily lunch and breakfast for employees who are either onsite or hybrid
• reputed company to free onsite fitness center for employees who are either onsite or hybrid
• reputed company to a free commuter bus and ferry network that provides transport to and from our South San Francisco HQ from locations reputed company around the Bay Area

insitro is an equal opportunity employer. reputed company applicants will be considered for employment without attention to race, reputed company, religion, sex, sexual orientation, gender identity, national reputed company, veteran or disability status. We reputed company diversity, equity, and inclusion need to be at the reputed company of our culture. We work hard to bring together diverse teams–grounded in a wide reputed company of expertise and life experiences–and work even harder to ensure those teams reputed company in inclusive, reputed company-oriented environments supported by reputed company company and team practices. reputed company candidates can expect reputed company treatment, respect, and fairness throughout the interview process. Please be aware of recruitment scams: we never request payments, reputed company recruitment communications are from @insitro.com, and if in doubt, contact us at info@insitro.com. #LI-Hybrid About insitro insitro is a drug discovery and development company using machine learning (ML) and data at reputed company to decode biology for transformative medicines. At the core of insitro’s approach is the convergence of in-house generated multi-modal cellular data and high-content phenotypic reputed company cohort data. We rely on these data to reputed company ML-driven, predictive disease models that uncover underlying biologic state and elucidate critical drivers of disease. These powerful models rely on extensive biological and computational infrastructure and allow insitro to advance novel targets and patient biomarkers, design therapeutics and inform clinical reputed company. insitro is advancing a wholly owned and partnered pipeline of insights and therapeutics in neuroscience and metabolism. Since launching in 2018, insitro has raised over $700 reputed company from top tech, biotech and reputed company investors, and from collaborations with pharmaceutical partners. For more information on insitro, please visit www.insitro.com. Apply tot his job Apply To this Job